Chelsea’s young defender Levi Colwill is also in the squad but there was no recall for his club team mate Raheem Sterling despite an impressive start to the new season.
Nketiah has been a stalwart of England’s under-21 squad and has started the season well for Arsenal with two goals in their opening three Premier League games.
“Two young players who are doing very well,” Southgate said of Nketiah and Colwill.
“They have done well with our junior teams. Levi had time with us in the summer.”
Southgate also kept faith with Manchester United defender Harry Maguire despite him not featuring for his club so far this season, while Jordan Henderson, who joined Saudi Arabian side Al-Ettifaq in July, was retained.
On leaving out Sterling again, Southgate said: “A lot of competition for places in that area behind the nine. Really happy to see him do well for Chelsea, but everyone has started the season well. Raheem’s not particularly happy.”
England, who are clear leaders of Group C, face Ukraine in Wroclaw, Poland, on Sept. 9 before facing Scotland in a friendly the following week.
Squad:
Goalkeepers: Sam Johnstone, Jordan Pickford, Aaron Ramsdale (Arsenal)
Defenders: Ben Chilwell, Levi Colwill, Lewis Dunk, Marc Guehi, Harry Maguire, Fikayo Tomori, Kieran Trippier, Kyle Walker
Midfielders: Trent Alexander-Arnold, Jude Bellingham, Conor Gallagher, Jordan Henderson, Kalvin Phillips, Declan Rice
Forwards: Eberechi Eze, Phil Foden, Jack Grealish, Harry Kane, James Maddison, Eddie Nketiah, Marcus Rashford, Bukayo Saka, Callum Wilson
(Reporting by Martyn Herman; Editing by Toby Davis)